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pentobarbital will lessen the level or effect of parecoxib by influencing hepatic enzyme CYP2C9/ten metabolism. Use Caution/Observe.pentobarbital will minimize the level or effect of alosetron by affecting hepatic enzyme CYP2C9/10 metabolism. Insignificant/Significance Unidentified.pentobarbital decreases amounts of vandetanib by influencing hepati